Anti-CASP4 Polyclonal Antibody
品牌：solarbio | 货号：K004571P
| 英文名称 | Anti-CASP4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CASP-11;CASP-4;Casp11;Caspl;ich-3 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 43kDa |
| Gene ID | 12363 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of mouse CASP4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of mouse CASP4 |
| Subcellular Locations | Endoplasmic reticulum Mitochondrion Cytosol secreted |
| Swiss Prot | P49662 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is “caspase 4, apoptosis-related cysteine peptidase”, this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. |