Anti-TRP12 Polyclonal Antibody
品牌：solarbio | 货号：K106822P
| 英文名称 | Anti-TRP12 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | VRL2;?VROAC;TRPV4 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 98kDa |
| Gene ID | 59341 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human TRP12 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human TRP12 |
| Subcellular Locations | Cytoplasm Cell membrane |
| Swiss Prot | Q9HBA0 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This protein play a important role in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. |