Anti-LDLR Polyclonal Antibody
品牌：solarbio | 货号：K106578P
| 英文名称 | Anti-LDLR Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | FH;FHC;LDLCQ2;LDLR |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 120kDa |
| Gene ID | 3949 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human LDLR |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human LDLR |
| Subcellular Locations | Cell membrane Cell surface Early endosome Endomembrane system Golgi apparatus Late endosome Lysosome Membrane Single-pass type I membrane protein clathrin-coated pit |
| Swiss Prot | P01130 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. |