Anti-TJP1 Polyclonal Antibody
品牌:solarbio | 货号:K008065P
英文名称 |
Anti-TJP1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ZO-1 |
应用 |
IHC |
稀释比例 |
IHC 1:30-150. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
195/187kDa |
Gene ID |
7082 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human TJP1 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human TJP1 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
Q07157 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. |