Anti-TJP1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-TJP1 Polyclonal Antibody

品牌:solarbio | 货号:K008065P

英文名称 Anti-TJP1 Polyclonal Antibody
宿主 Rabbit
别名 ZO-1
应用 IHC
稀释比例 IHC 1:30-150.
交叉反应 Human Mouse Rat
蛋白分子量 195/187kDa
Gene ID 7082
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human TJP1
性状 液体
Public Immunogen Range A synthetic peptide of human TJP1
Subcellular Locations Cytoplasm
Swiss Prot Q07157
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms.