Anti-CDKL1 Polyclonal Antibody
品牌：solarbio | 货号：K007997P
| 英文名称 | Anti-CDKL1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | P42;KKIALRE |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:20-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 42kDa |
| Gene ID | 8814 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CDKL1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CDKL1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q00532 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif. |