Anti-APAF1 Polyclonal Antibody
品牌：solarbio | 货号：K007367P
| 英文名称 | Anti-APAF1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CED4 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 142kDa |
| Gene ID | 317 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human APAF1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human APAF1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | O14727 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. |