Anti-PRKAR2A Polyclonal Antibody
品牌：solarbio | 货号：K007141P
| 英文名称 | Anti-PRKAR2A Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | PKR2;PRKAR2 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:35-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 46kDa |
| Gene ID | 5576 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PRKAR2A |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PRKAR2A |
| Subcellular Locations | Cytoplasm Cell membrane |
| Swiss Prot | P13861 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). |