Anti-ALOXE3 Polyclonal Antibody
品牌：solarbio | 货号：K006893P
| 英文名称 | Anti-ALOXE3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ARCI3;E-LOX;eLOX3;eLOX-3 |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 80kDa |
| Gene ID | 59344 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ALOXE3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ALOXE3 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q9BYJ1 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene. |