Anti-DUSP10 Polyclonal Antibody
品牌：solarbio | 货号：K006741P
| 英文名称 | Anti-DUSP10 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | MKP5;MKP-5 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 53kDa |
| Gene ID | 11221 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human DUSP10 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human DUSP10 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q9Y6W6 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus.? |