Anti-CBL Polyclonal Antibody
品牌：solarbio | 货号：K005526P
| 英文名称 | Anti-CBL Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | C-CBL;CBL2;FRA11B;NSLL;RNF55 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 100kDa |
| Gene ID | 867 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CBL |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CBL |
| Subcellular Locations | Cell membrane Cytoplasm |
| Swiss Prot | P22681 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5′ UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. |