Anti-ARID1A Polyclonal Antibody
品牌：solarbio | 货号：K005343P
| 英文名称 | Anti-ARID1A Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | 1110030E03Rik;BAF250a;Osa1;Smarcf1 |
| 应用 | IF |
| 稀释比例 | IF 1:50-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 242kDa |
| Gene ID | 93760 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of mouse ARID1A |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of mouse ARID1A |
| Subcellular Locations | Nucleus |
| Swiss Prot | A2BH40 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. |