Anti-ACTN2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-ACTN2 Polyclonal Antibody

品牌:solarbio | 货号:K003686P

英文名称 Anti-ACTN2 Polyclonal Antibody
宿主 Rabbit
别名 CMD1AA;CMH23
应用 WB IF
稀释比例 WB 1:500-2000. IF 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 104kDa
Gene ID 88
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human ACTN2
性状 液体
Public Immunogen Range Recombinant protein of human ACTN2
Subcellular Locations Cytoplasm Z line myofibril sarcomere
Swiss Prot P35609
克隆类型 Polyclonal Antibody
背景资料 Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.