Anti-ACTN2 Polyclonal Antibody
品牌:solarbio | 货号:K003686P
英文名称 |
Anti-ACTN2 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CMD1AA;CMH23 |
应用 |
WB IF |
稀释比例 |
WB 1:500-2000. IF 1:50-200. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
104kDa |
Gene ID |
88 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human ACTN2 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human ACTN2 |
Subcellular Locations |
Cytoplasm Z line myofibril sarcomere |
Swiss Prot |
P35609 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. |