Anti-GNAS Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-GNAS Polyclonal Antibody

品牌:solarbio | 货号:K008154P

英文名称 Anti-GNAS Polyclonal Antibody
宿主 Rabbit
别名 AHO;GSA;GSP;POH;GPSA;NESP;GNAS1;PHP1A;PHP1B;PHP1C;C20orf45
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:25-100.
交叉反应 Human Mouse Rat
蛋白分子量 46kDa
Gene ID 2778
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human GNAS
性状 液体
Public Immunogen Range Recombinant protein of human GNAS
Subcellular Locations Cytoplasm
Swiss Prot P63092
克隆类型 Polyclonal Antibody
背景资料 This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5′ exons. Some transcripts contain a differentially methylated region (DMR) at their 5′ exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein – Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.?