Anti-MME Polyclonal Antibody
品牌：solarbio | 货号：K004118P
| 英文名称 | Anti-MME Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CALLA;CD10;CMT2T;NEP;SCA43;SFE |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 86kDa |
| Gene ID | 4311 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human MME |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human MME |
| Subcellular Locations | Cell membrane Single-pass type II membrane protein |
| Swiss Prot | P08473 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5′ untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. |