Anti-IL12 Polyclonal Antibody
品牌:solarbio | 货号:K106473P
英文名称 |
Anti-IL12 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
IL-12A;CLMF p35;IL-12 subunit p35;NKSF1;IL12A |
应用 |
WB |
稀释比例 |
WB 1:3000. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
52kDa |
Gene ID |
3592 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human IL12 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human IL12 |
Subcellular Locations |
Cell membrane Secreted |
Swiss Prot |
P29459 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
IL-12 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. |