Anti-CD22 Polyclonal Antibody
品牌：solarbio | 货号：K006342P
| 英文名称 | Anti-CD22 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | SIGLEC-2;SIGLEC2 |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:10-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 95kDa |
| Gene ID | 933 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CD22 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CD22 |
| Subcellular Locations | Cell membrane Single-pass type I membrane protein |
| Swiss Prot | P20273 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through. |