Anti-NPRL2 Polyclonal Antibody
品牌：solarbio | 货号：K007781P
| 英文名称 | Anti-NPRL2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | NPR2;NPR2L;TUSC4 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 44kDa |
| Gene ID | 10641 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human NPRL2 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human NPRL2 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q8WTW4 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events. |