Anti-TAB1 Polyclonal Antibody
品牌：solarbio | 货号：K008371P
| 英文名称 | Anti-TAB1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | TAB 1;TAK1;TGF beta activated kinase 1 binding protein 1;MAP3K7IP 1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:100-300. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 55kDa |
| Gene ID | 10454 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human TAB1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human TAB1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q15750 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. |