Anti-CCM2 Polyclonal Antibody
品牌：solarbio | 货号：K004601P
| 英文名称 | Anti-CCM2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | C7orf22;OSM;PP10187 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 49kDa |
| Gene ID | 83605 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CCM2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CCM2 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q9BSQ5 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. |