Anti-ALS2 Polyclonal Antibody
品牌：solarbio | 货号：K005033P
| 英文名称 | Anti-ALS2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ALS2CR6;ALSJ;IAHSP;PLSJ |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 184kDa |
| Gene ID | 57679 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ALS2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ALS2 |
| Subcellular Locations | Cytoskeleton Cytosol Endosome |
| Swiss Prot | Q96Q42 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. |