Anti-FUBP1 Polyclonal Antibody
品牌：solarbio | 货号：K004075P
| 英文名称 | Anti-FUBP1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | FBP;FUBP;hDH V |
| 应用 | WB IHC IP |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IP 1:50-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 68kDa |
| Gene ID | 8880 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human FUBP1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human FUBP1 |
| Subcellular Locations | Nucleus |
| Swiss Prot | Q96AE4 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3′-5′ helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. |