Anti-FBLN5 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-FBLN5 Polyclonal Antibody

品牌:solarbio | 货号:K007433P

英文名称 Anti-FBLN5 Polyclonal Antibody
宿主 Rabbit
别名 EVEC;UP50;ADCL2;ARMD3;DANCE;ARCL1A;FIBL-5
应用 IHC
稀释比例 IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 50kDa
Gene ID 10516
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human FBLN5
性状 液体
Public Immunogen Range A synthetic peptide of human FBLN5
Subcellular Locations Cytoplasm
Swiss Prot Q9UBX5
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).