Anti-SPATA13 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-SPATA13 Polyclonal Antibody

品牌:solarbio | 货号:K006838P

英文名称 Anti-SPATA13 Polyclonal Antibody
宿主 Rabbit
别名 ASEF2;ARHGEF29;RP11-307N16.3
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:25-100.
交叉反应 Human Mouse
蛋白分子量 75kDa
Gene ID 221178
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human SPATA13
性状 液体
Public Immunogen Range Recombinant protein of human SPATA13
Subcellular Locations Cytoplasm
Swiss Prot Q96N96
克隆类型 Polyclonal Antibody
背景资料 Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.