Anti-FBXW7 Polyclonal Antibody
品牌：solarbio | 货号：K004271P
| 英文名称 | Anti-FBXW7 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AGO;CDC4;FBW6;FBW7;FBX30;FBXO30;FBXW6;SEL-10;SEL10;hAgo;hCdc4 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 80kDa |
| Gene ID | 55294 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human FBXW7 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human FBXW7 |
| Subcellular Locations | Cytoplasm Nucleus nucleolus nucleoplasm |
| Swiss Prot | Q969H0 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene’s potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. |