Anti-DUSP4 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-DUSP4 Polyclonal Antibody

品牌:solarbio | 货号:K008150P

英文名称 Anti-DUSP4 Polyclonal Antibody
宿主 Rabbit
别名 TYP;HVH2;MKP2;MKP-2
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-150.
交叉反应 Human Mouse Rat
蛋白分子量 43kDa
Gene ID 1846
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human DUSP4
性状 液体
Public Immunogen Range Recombinant protein of human DUSP4
Subcellular Locations Cytoplasm Nucleus
Swiss Prot Q13115
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.