Anti-HRAS Polyclonal Antibody
品牌：solarbio | 货号：K007381P
| 英文名称 | Anti-HRAS Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CTLO;HAMSV;HRAS1;RASH1;p21ras;C-H-RAS;H-RASIDX;C-BAS/HAS;C-HA-RAS1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:25-50. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 21kDa |
| Gene ID | 3265 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human HRAS |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human HRAS |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P01112 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. |