Anti-ATM Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-ATM Polyclonal Antibody

品牌:solarbio | 货号:K004295P

英文名称 Anti-ATM Polyclonal Antibody
宿主 Rabbit
别名 AT1;ATA;ATC;ATD;ATDC;ATE;TEL1;TELO1
应用 WB
稀释比例 WB 1:500-1000.
交叉反应 Human
蛋白分子量 351kDa
Gene ID 472
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human ATM
性状 液体
Public Immunogen Range A synthetic peptide of human ATM
Subcellular Locations Cytoplasmic vesicle Nucleus
Swiss Prot Q13315
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.