Anti-EID1 Polyclonal Antibody
品牌:solarbio | 货号:K007024P
英文名称 |
Anti-EID1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CRI1;EID-1;RBP21;PTD014;C15orf3;PNAS-22;IRO45620 |
应用 |
WB IHC |
稀释比例 |
WB 1:200-1000. IHC 1:25-100. |
交叉反应 |
Human Mouse |
蛋白分子量 |
21kDa |
Gene ID |
23741 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human EID1 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human EID1 |
Subcellular Locations |
Nucleus Cytoplasm |
Swiss Prot |
Q9Y6B2 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator. |