Anti-AXIN2 Polyclonal Antibody
品牌：solarbio | 货号：K006954P
| 英文名称 | Anti-AXIN2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AXIL;ODCRCS |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 94kDa |
| Gene ID | 8313 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human AXIN2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human AXIN2 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q9Y2T1 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |