Anti-PSTPIP1 Polyclonal Antibody
品牌：solarbio | 货号：K005446P
| 英文名称 | Anti-PSTPIP1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CD2BP1;CD2BP1L;CD2BP1S;H-PIP;PAPAS;PSTPIP |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 48kDa |
| Gene ID | 9051 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PSTPIP1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PSTPIP1 |
| Subcellular Locations | Cell projection Cleavage furrow Cytoplasm cytoskeleton lamellipodium perinuclear region uropodium |
| Swiss Prot | O43586 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. |