Anti-TGFB2 Polyclonal Antibody
品牌:solarbio | 货号:K003684P
英文名称 |
Anti-TGFB2 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
G-TSF;LDS4;TGF-beta2 |
应用 |
WB IF |
稀释比例 |
WB 1:200-2000. IF 1:50-200. |
交叉反应 |
Human MouseRat |
蛋白分子量 |
48kDa |
Gene ID |
7042 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant Protein of human TGFB2 |
性状 |
液体 |
Public Immunogen Range |
Recombinant Protein of human TGFB2 |
Subcellular Locations |
Secreted |
Swiss Prot |
P61812 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters’ anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. |