Anti-Phospho-PRKACA-T197 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-Phospho-PRKACA-T197 Polyclonal Antibody

品牌:solarbio | 货号:K006238P

英文名称 Anti-Phospho-PRKACA-T197 Polyclonal Antibody
宿主 Rabbit
别名 PKACA;PPNAD4
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Human Mouse Rat
蛋白分子量 41kDa
Gene ID 5566
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A phospho specific peptide corresponding to residues surrounding T197 of human PRKACA
性状 液体
Public Immunogen Range A phospho specific peptide corresponding to residues surrounding T197 of human PRKACA
Subcellular Locations Cell membrane Cell projection Cytoplasm Lipid-anchor Membrane Mitochondrion Nucleus cilium flagellum
Swiss Prot P17612
克隆类型 Polyclonal Antibody
背景资料 This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing’s syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.