Anti-RFX5 Polyclonal Antibody
品牌:solarbio | 货号:K004902P
英文名称 |
Anti-RFX5 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
RFX5 |
应用 |
WB IF |
稀释比例 |
WB 1:500-2000. IF 1:50-100. |
交叉反应 |
Human |
蛋白分子量 |
65kDa |
Gene ID |
5993 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human RFX5 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human RFX5 |
Subcellular Locations |
Nucleus |
Swiss Prot |
P48382 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. |