Anti-ERBB3 Polyclonal Antibody
品牌：solarbio | 货号：K006703P
| 英文名称 | Anti-ERBB3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HER3;LCCS2;ErbB-3;c-erbB3;erbB3-S;MDA-BF-1;c-erbB-3;p180-ErbB3;p45-sErbB3;p85-sErbB3 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-150. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 148kDa |
| Gene ID | 2065 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ERBB3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ERBB3 |
| Subcellular Locations | Cytoplasm Cell membrane |
| Swiss Prot | P21860 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. |