Anti-ACVR1 Polyclonal Antibody
品牌：solarbio | 货号：K008353P
| 英文名称 | Anti-ACVR1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | FOP;ALK2;SKR1;TSRI;ACTRI;ACVR1A;ACVRLK2 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 57kDa |
| Gene ID | 90 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ACVR1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ACVR1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q04771 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |