Anti-CASP14 Polyclonal Antibody
品牌：solarbio | 货号：K004598P
| 英文名称 | Anti-CASP14 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ARCI12 |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:10-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 28kDa |
| Gene ID | 23581 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CASP14 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CASP14 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P31944 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. |