Anti-MDM2 Polyclonal Antibody
品牌:solarbio | 货号:K106576P
英文名称 |
Anti-MDM2 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ACTFS;hdm2;HDMX;E3 ubiquitin-protein ligase Mdm2 |
应用 |
WB |
稀释比例 |
WB 1:3000. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
48kDa |
Gene ID |
4193 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human MDM2 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human MDM2 |
Subcellular Locations |
Nucleus |
Swiss Prot |
Q00987 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX. |