Anti-CRTAM Polyclonal Antibody
品牌:solarbio | 货号:K006716P
英文名称 |
Anti-CRTAM Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CD355 |
应用 |
WB IHC |
稀释比例 |
WB 1:500-2000. IHC 1:50-200. |
交叉反应 |
Human |
蛋白分子量 |
45kDa |
Gene ID |
56253 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human CRTAM |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human CRTAM |
Subcellular Locations |
cytoplasm |
Swiss Prot |
O95727 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Class-I MHC-restricted T cell associated molecule (CRTAM) is a receptor that is primarily expressed on activated cytotoxic lymphocytes, where it may play a role in their adhesion, interaction or migration. It is one of the most highly expressed surface markers detected on activated human NK T cells and CD8 T cells, suggesting its use as a diagnostic tool in various human viral and autoimmune diseases. CRTAM binds nectin-like protein 2 (necl2), which is involved in IL-22 expression regulation. This Necl2/CRTAM molecular pair may regulate cell/cell interactions and may play a role in neuronal interactions. CRTAM is also highly expressed in Purkinje neurons in the cerebellum. |