Anti-CRTAM Polyclonal Antibody
品牌：solarbio | 货号：K006716P
| 英文名称 | Anti-CRTAM Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CD355 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 45kDa |
| Gene ID | 56253 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CRTAM |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CRTAM |
| Subcellular Locations | cytoplasm |
| Swiss Prot | O95727 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Class-I MHC-restricted T cell associated molecule (CRTAM) is a receptor that is primarily expressed on activated cytotoxic lymphocytes, where it may play a role in their adhesion, interaction or migration. It is one of the most highly expressed surface markers detected on activated human NK T cells and CD8 T cells, suggesting its use as a diagnostic tool in various human viral and autoimmune diseases. CRTAM binds nectin-like protein 2 (necl2), which is involved in IL-22 expression regulation. This Necl2/CRTAM molecular pair may regulate cell/cell interactions and may play a role in neuronal interactions. CRTAM is also highly expressed in Purkinje neurons in the cerebellum. |