Anti-BIN1 Polyclonal Antibody
品牌：solarbio | 货号：K006680P
| 英文名称 | Anti-BIN1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AMPH2;AMPHL;SH3P9 |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human |
| 蛋白分子量 | 65kDa |
| Gene ID | 274 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human BIN1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human BIN1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | O00499 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. |