Anti-PDK3 Polyclonal Antibody
品牌：solarbio | 货号：K005628P
| 英文名称 | Anti-PDK3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CMTX6;GS1-358P8.4 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 47kDa |
| Gene ID | 5165 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PDK3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PDK3 |
| Subcellular Locations | Mitochondrion matrix |
| Swiss Prot | Q15120 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |