Anti-Phospho-ALOX5-S271 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-Phospho-ALOX5-S271 Polyclonal Antibody

品牌:solarbio | 货号:K006242P

英文名称 Anti-Phospho-ALOX5-S271 Polyclonal Antibody
宿主 Rabbit
别名 5-LO;5-LOX;5LPG;LOG5
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Human
蛋白分子量 78kDa
Gene ID 240
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A phospho specific peptide corresponding to residues surrounding S271 of human ALOX5
性状 液体
Public Immunogen Range A phospho specific peptide corresponding to residues surrounding S271 of human ALOX5
Subcellular Locations Cytoplasm Nucleus matrix Nucleus membrane Peripheral membrane protein
Swiss Prot P09917
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.