Anti-MT-ND1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-MT-ND1 Polyclonal Antibody

品牌:solarbio | 货号:K007773P

英文名称 Anti-MT-ND1 Polyclonal Antibody
宿主 Rabbit
别名 MTND1;ND1
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 36kDa
Gene ID 4535
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human MT-ND1
性状 液体
Public Immunogen Range A synthetic peptide of human MT-ND1
Subcellular Locations Cytoplasm
Swiss Prot P03886
克隆类型 Polyclonal Antibody
背景资料 NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Human complex I is important for energy metabolism because its main function is to transport electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits. A small number of complex I subunits are the products of mitochondrial genes (subunits 1-7), while the remainder are nuclear encoded and imported from the cytoplasm. NADH dehydrogenase subunit 1 (ND1) binds rotenone and rotenone analogs and might be involved in electron transfer to ubiquinone. Mutations in the ND1 gene may be implicated in several disorders, including Leber hereditary optic neuropathy, Alzheimer disease, and Parkinson disease.