Cy7.5-N-羟基琥珀酰亚胺酯|Cyanine7.5 NHS ester|金畔生物


Cy7.5-N-羟基琥珀酰亚胺酯

货号:AGF1356A-25mg
包装:25mg

  • 英文名:Cyanine7.5 NHS ester
  • 分子式:C49H52ClN3O4
  • 分子量:782.41
  • 品牌:lumiprobe
  • 外观:green powder
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    onclick=”switchExtendAttrTab(‘detail0’,2)”>产品详情质检信息

    订购货号 产品名称及规格
    16020 Cyanine7.5 NHS ester, 1 mg
    26020 Cyanine7.5 NHS ester, 5 mg
    46020 Cyanine7.5 NHS ester, 25 mg
    56020 Cyanine7.5 NHS ester, 50 mg
    66020 Cyanine7.5 NHS ester, 100 mg

    Cyanine7.5是一种近红外荧光染料,具有很长的发射光谱,是此类荧光衍生而来的活性胺产品。

    近红外照射很容易穿透组织因此常应用于体内成像领域。
    该产品可以用于标记含有氨基的小分子物质,比如蛋白和多肽,通过近红外光谱成像技术(NIR imaging)来示踪他们在有机体内的分布。
    中心聚亚甲基基团的增强的稳定性使得量子产率较其母结构Cy7.5® NHS提高20%。
    Cy7.5-N-羟基琥珀酰亚胺酯|Cyanine7.5 NHS ester|金畔生物
    推荐手册
    Cy® is a trademark of GE Healthcare.

    General properties

     

    Appearance: green powder
    Molecular weight: 782.41
    Molecular formula:

    C49H52ClN3O4

    Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
    Quality control: NMR 1H (95%) and 13C, TLC, functional testing
    Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
    MSDS: Download

    Spectral properties

     

    Excitation maximum, nm: 788
    Extinction coefficient at excitation maximum, Lmol-1cm-1: 223000
    Emission maximum, nm: 808

     

    Product citations

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    2. Dou, Y.; Guo, J.; Chen, Y.; Han, S.; Xu, X.; Shi, Q.; Jia, Y.; Liu, Y.; Deng, Y.; Wang, R.; Li, X.; Zhang, J. Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice. Journal of Controlled Release2016, 235, 48–62. doi: 10.1016/j.jconrel.2016.05.049
    3. Markovic, S.; Belz, J.; Kumar, R.; Cormack, R.A.; Sridhar, S.; Niedre, M. Near-infrared fluorescence imaging platform for quantifying in vivo nanoparticle diffusion from drug loaded implants. International Journal of Nanomedicine2016, 11, 1213–1223. doi: 10.2147/IJN.S93324
    4. Han, F.Y.; Thurecht, K.J.; Lam, A.-L.; Whittaker, A.K.; Smith, M.T. Novel Polymeric Bioerodable Microparticles for Prolonged-Release Intrathecal Delivery of Analgesic Agents for Relief of Intractable Cancer-Related Pain. Journal of Pharmaceutical Sciences2015, 104(7), 2334–2344. doi: 10.1002/jps.24497
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    6. Duong, H.T.T.; Dong, Z.; Su, L; Boyer, C.; George, J.; Davis, T.P.; Wang, J. The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension. Small2015, 11(19), 2291–2304.201402870
    7. Chen, K.; Xu, X.; Guo, J.W.; Zhang, X.; Han, S.; Wang, R.; Li, X.; Zhang, J. Enhanced Intracellular Delivery and Tissue Retention of Nanoparticles by Mussel-Inspired Surface Chemistry. Biomacromolecules2015, 16(11), 3574–3583. doi:10.1021/acs.biomac.5b01056
    8. Lin, Y.-A.; Cheetham, A.G.; Zhang, P.; Ou, Y.-C.; Li, Y.; Liu, G.; Hermida Merino, D.; Hamley, I.W.; Cui, H. Multi-Walled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles. ACS Nano2014, 8(12), 12690-12700. doi: 10.1021/nn505688b
    9. Graen, T.M.D.; Hoefling, M.; Grubmüller, H. AMBER-DYES: Characterization of Charge Fluctuations and Force Field Parameterization of Fluorescent Dyes for Molecular Dynamics Simulations. Journal of Chemical Theory and Computation2014, 10(12), 5505-5512. doi: 10.1021/ct500869p
    10. Lu, H.D.; Soranno, D.E.; Rodell, C.B.; Kim, I.L.; Burdick, J.A. Secondary Photocrosslinking of Injectable Shear-Thinning Dock-and-Lock Hydrogels. Advanced Healthcare Materials2013, 2(7), 1028-1036. doi: 10.1002/adhm.201200343
    11. Yang, H.; Mao, H.; Wan, Z.; Zhu, A.; Guo, M.; Li, Y.; Li, X.; Wan, J.; Yang, X.; Shuai, X. et al. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials2013, 34(36), 9124-9133. doi: 10.1016/j.biomaterials.2013.08.022
    12. </