| 有效期 | 2年 |
|---|---|
| 溶解性 | 10mg/Ml in DMSO |
| 来源 | 青霉菌 |
| 别名 | PMA,TPA,Phorbol ester,croton oil |
| 英文名称 | Phorbol 12-myristate 13-acetate |
| CAS | 16561-29-8 |
| 分子式 | C36H56O8 |
| 分子量 | 616.8 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 单位 | 瓶 |
PMA（同义名：TPA）是一种广泛用于体内外实验的佛波酯(phorbol ester) PKC激活剂。PMA结合PKC(Ki =2.6 nM)并激活其功能，在细胞和组织中都呈现出极其广的抑制谱。PMA可以抑制Fas诱导的细胞凋亡，但又可以诱导HL-60细胞的凋亡。PMA是一种高效的肿瘤促进剂，可以促进小鼠皮肤瘤的形成。尽管PMA毒性较强，但是在人体内仍显示出抗白血病和抗中性白细胞减少的活性。
使用浓度：
PMA的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。
Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
CAS Number: 16561-29-8
Storage：-20°C.
Synonyms: PMA, TPA, Phorbol ester, croton oil.
Formulation: Crystalline solid
Chemical Name: 12-O-Tetradecanoylphorbol-13-acetate
Molecular Formula: C36H56O8
Molecular Weight：616.8
Purity:≥98%
Description:
Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
Preparation and storage:
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 100mM..
本产品可能不适合用于诱导THP-1细胞分化为巨噬细胞。
备注：产品信息可能会有优化升级。请以实际标签信息为准。