Anti-CPEB4 (N-term) Polyclonal Antibody
品牌：solarbio | 货号：K006384P
| 英文名称 | Anti-CPEB4 (N-term) Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CPEB4 (N-term) |
| 应用 | WB IHC-P |
| 稀释比例 | WB 1:1000. IHC 1:50-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 80kDa |
| Gene ID | |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | Ig |
| 免疫原 | synthetic peptide between 109-137 amino acids |
| 性状 | 液体 |
| Public Immunogen Range | synthetic peptide between 109-137 amino acids |
| Subcellular Locations | Plasma membrane Endoplasmic reticulum |
| Swiss Prot | Q17RY0 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5′-UUUUUAU-3′) within the mRNA 3′-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). |