Anti-UPF1 Polyclonal Antibody
品牌:solarbio | 货号:K007655P
英文名称 |
Anti-UPF1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
HUPF1;NORF1;RENT1;smg-2;pNORF1 |
应用 |
WB IHC |
稀释比例 |
WB 1:200-1000. IHC 1:50-200. |
交叉反应 |
Human Mouse |
蛋白分子量 |
124kDa |
Gene ID |
5976 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human UPF1 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human UPF1 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
Q92900 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.? |