Anti-CHK1 Polyclonal Antibody
品牌：solarbio | 货号：K106874P
| 英文名称 | Anti-CHK1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CHEK1;checkpoint kinase 1 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 54kDa |
| Gene ID | 1111 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CHK1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CHK1 |
| Subcellular Locations | Nucleus Cytoplasm |
| Swiss Prot | O14757 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. |