Anti-APITD1 Polyclonal Antibody
品牌：solarbio | 货号：K005741P
| 英文名称 | Anti-APITD1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CENPS;APITD1;CENP-S;FAAP16;MHF1; |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human |
| 蛋白分子量 | 16kDa |
| Gene ID | 378708 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human APITD1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human APITD1 |
| Subcellular Locations | Chromosome Nucleus centromere kinetochore |
| Swiss Prot | Q8N2Z9 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. |