Anti-RBP3 Polyclonal Antibody
品牌：solarbio | 货号：K004498P
| 英文名称 | Anti-RBP3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | D10S64;D10S65;D10S66;IRBP;RBPI;RP66 |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 135kDa |
| Gene ID | 5949 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human RBP3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human RBP3 |
| Subcellular Locations | Secreted extracellular matrix extracellular space interphotoreceptor matrix |
| Swiss Prot | P10745 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. |