Anti-ACY1 Polyclonal Antibody
品牌：solarbio | 货号：K006902P
| 英文名称 | Anti-ACY1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ACY-1;ACY1D |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 46kDa |
| Gene ID | 95 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ACY1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ACY1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q03154 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. |